N of One: Autism Research Foundation

N of One: Autism Research Foundation N of One: Autism Research Foundation is a non-profit that sponsors breakthrough autism research. Please See More at: www.NofOne.org N of One is a non-profit that has been formed to raise funds for and a facilitate research into the biological basis for autism.

The founder of N of One, a parent of an autistic child, was a medical venture capitalist and brings that same approach of small dollars, big results to autism research.

The founder of N of One, a parent of an autistic child, was a medical venture capitalist and brings that same approach of small dollars, big results to autism research.

Operating as usual

*SURAMIN UPDATE*N of One has been a supporter and advocate for Dr. Robert Naviaux's autism research since our inception ...
02/11/2021
PaxMedica Announces Positive Results from Phase 2 Trial of PAX-101 (IV suramin) in Children with Autism Spectrum Disorder (ASD)

*SURAMIN UPDATE*

N of One has been a supporter and advocate for Dr. Robert Naviaux's autism research since our inception in 2014. That story has now taken another encouraging step forward with the biotech company, PaxMedica, announcing positive results from its recent clinical trial conducted in South Africa testing suramin for autism.

We will provide a more in-depth analysis in an upcoming newsletter to subscribers but highlights are below:

The Results:
In a double-blind, placebo-controlled trial, suramin was tested in 43 individuals over 14 weeks at two different doses. PaxMedica reports a 48% improvement in the ABC-core, a broad-based measure of multiple autism symptoms, vs. 31% improvement for the placebo group. They also claim positive results on other symptom evaluations. Importantly the reports are that suramin was safe and well-tolerated in the trial over the duration, with a relatively low rate of side effects.

What's notable about the trial?
For starters this is the first time that suramin has been given in multiple doses in children for ASD. The prior SAT-1 trial, which N of One supported, was only for a single dose out of potential safety concerns. Though there were side-effects in the PaxMedica trial, the safety profile looks encouraging

Additionally there are now TWO biotech companies pursuing suramin for autism: PaxMedica and Kuzani. A race to develop suramin is now underway; hopefully our kids will be the winners!

There is a LOT to unpack on this recent suramin development and we will be discussing the findings and implications soon to our newsletter subscribers. If you'd like to receive that, you can sign up at our website.

We have more information about such as how suramin is thought to work, a detailed summary of the previous trial, and an in-depth interview with Dr. Robert Naviaux at our website www.NofOne.org

https://www.prnewswire.com/news-releases/paxmedica-announces-positive-results-from-phase-2-trial-of-pax-101-iv-suramin-in-children-with-autism-spectrum-disorder-asd-301224425.html

/PRNewswire/ -- PaxMedica, Inc. ("PaxMedica" or the "Company"), a biopharmaceutical company focused on the development and commercialization of innovative...

N of One: Autism Research Foundation's cover photo
10/09/2020

N of One: Autism Research Foundation's cover photo

A great virtual conference on the latest autism research and treatment from our friends at the Brain Foundation.The even...
10/09/2020

A great virtual conference on the latest autism research and treatment from our friends at the Brain Foundation.

The event fee goes to support autism research. Highly encourage you to consider participating!

The long wait is over!

🔴 The BRAIN Foundation, in partnership with UC Davis MIND Institute and CalTech, is excited to announce the second year of Synchrony.

🔴 Synchrony is the first and only international symposium on translational research in autism, that brings together academia, biotech, pharmaceutical companies and venture partners from around the world with the mission to improve health and quality of life of people with autism.

🔴 Come learn about the latest in basic and translational research and the opportunities being pursued by biotech and pharmaceutical companies for the development of FDA-approved therapeutics for autism.

https://synchronysymposium.com/

#SynchronySymposia
#ucdavis #UCDavisHealth #mindinstitute #Caltech #synchrony2020 #biotech #translationalresearch #autism #ASD #biopharmaceutical #neuroimmune #autismtreatment #medicalcomorbidity #microbiome #gutbrainconnection #ORGANOID

“It was completely life altering.” said the mother of a trial participant.N of One is actively engaged in shaping & supp...
08/24/2020
Could the gut microbiome be linked to autism?

“It was completely life altering.” said the mother of a trial participant.

N of One is actively engaged in shaping & supporting clinical microbiome research that will lead to treatments. Learn more at: NofOne.org

Researchers are hoping to understand whether the microbes in our guts have a role in the disorder.

CALIFORNIA RESIDENTS:Can autism risk be identified in routine newborn screenings? We need your help to find out. If you ...
02/25/2020
UCSD seeks volunteers for study that will try to identify risk of autism before symptoms appear

CALIFORNIA RESIDENTS:
Can autism risk be identified in routine newborn screenings? We need your help to find out. If you have a child 3-10yo with autism born in CA, you can help by allowing your child’s newborn blood spot to be examined in an N of One supported study. (NO blood test necessary!)

Please tag CA friends who may be interested

Follow the link below to help these children with minimal effort on your part

Researchers will look for "tell-tale" signs of the disorder in blood samples taken when a child is born

Excellent article about ongoing study from N of One supported researcher Dr. Robert Naviaux.One N of One's core efforts ...
02/13/2020
Predicting Autism Risk May Begin with a Drop of Blood

Excellent article about ongoing study from N of One supported researcher Dr. Robert Naviaux.

One N of One's core efforts has been to understand the finding that persons with autism seem to have a shared blood chemistry signature. This can potentially be used to diagnose and predict which children may be at risk - before they display symptoms.

California Participants needed! NO blood draw reqd. Blood spots collected at birth by the state will be used. Link in article for more details

Within days of birth, a few drops of blood are collected from every newborn in California—and across the United States—which are then stored on filter paper and screened for dozens of genetic and congenital disorders, such as phenylketonuria (PKU), an inherited metabolic disorder that can result...

Just published Harvard Medical School study:"Our findings suggest that immune system activation during critical periods ...
11/19/2019
Maternal and early postnatal immune activation produce sex-specific effects on autism-like behaviors and neuroimmune function in mice

Just published Harvard Medical School study:

"Our findings suggest that immune system activation during critical periods of development is sufficient to produce persistent alterations in behavior and brain biology—even in the absence of accompanying genetic vulnerability"

Adds to the growing body of evidence that early (pre-&post-natal) immune activation plays key role in neurodevelopmental disorders like autism later in life.

We hope to write more about this in the coming weeks to our newsletter subscribers. Subscribe here: http://bit.ly/NofOneSignup

Increasing evidence suggests a role for inflammation in neuropsychiatric conditions including autism spectrum disorder (ASD), a neurodevelopmental syndrome with higher prevalence in males than females. Here we examined the effects of early-life immune system activation (EIA)—comprising regimens of...

11/13/2019

Kudos to The Brain Foundation for organizing the Synchrony conference, an International Symposium on Translational Research in Autism this past weekend in Pleasanton Ca.

It was an incredible gathering of researchers, clinicians, autism community members and parents. Updates on promising research from N of One supported researchers such as Robert Naviaux, Richard Frye, Sarkis Mazmanian and many others were presented.

What was most encouraging was seeing leading researchers from emerging autism fields such as the microbiome, the immune system, and cell metabolism, learning about each others research and discussing future collaborations.

The venue, the people, the events were top-notch. High compliments to Brain Foundation's leaders, Pramila Srinivasan, Elizabeth Horn, Gita Gupta & Sarika Agrawall and the rest of their team for conceiving and pulling off an ambitious agenda

If they do it again, I would highly encourage those interested in learning first hand about emerging autism research and clinical trials to attend this valuable event.

"Additional research funding is welcome and warranted as the prevalence continues to rise and the argument that it's jus...
10/04/2019
Government's $1.8 billion funding of autism research does not do enough to address the diagnosis gender gap, say experts

"Additional research funding is welcome and warranted as the prevalence continues to rise and the argument that it's just 'better awareness' no longer passes muster,"

-John Rodakis, Founder N of One: Autism Research Foundation, told Newsweek.

"My hope is that some of that additional research funding will be directed beyond genetics to newly emerging areas like the microbiome and the immune system that have been historically underfunded and hold great promise."

The Autism CARES Act of 2019 will see funding go towards people with autism spectrum disorder (ASD) and their families—a package that will be spread out over a five-year period.

N of One: Autism Research Foundation
09/23/2019

N of One: Autism Research Foundation

N of One: Autism Research Foundation's cover photo
09/23/2019

N of One: Autism Research Foundation's cover photo

TODAY IS THE DAY!You have until midnight to get your donation matched.Your gift makes a bigger impact TODAY because of m...
09/19/2019

TODAY IS THE DAY!
You have until midnight to get your donation matched.
Your gift makes a bigger impact TODAY because of matching dollars available and other NTXGD bonuses! And TODAY, any donation of $100 or more will be MATCHED up to $25,000! https://www.northtexasgivingday.org/index.php?section=organizations&action=newDonation_org&fwID=1682

DONATIONS DRIVE PROGRESS.
If you haven’t already, please "Get up and Give” to help N of One continue to fund targeted, innovative research that is getting us closer to life-changing answers for all those living with autism. Already delivering promising results, we need YOUR SUPPORT in order to maintain the momentum and progress this research.

It’s almost time for our one-day online fundraiser powered by Communities Foundation of Texas/North Texas Giving Day, Se...
09/18/2019

It’s almost time for our one-day online fundraiser powered by Communities Foundation of Texas/North Texas Giving Day, September 19th. However, scheduled giving is already open...and, we are excited to announce, one of our supporters has offered to match any $100 or more donation up to $25,000.

DONATIONS DRIVE PROGRESS so don’t wait, visit https://www.northtexasgivingday.org/index.php?section=organizations&action=newDonation_org&fwID=1682 and schedule your gift today!

Help us continue to progress the targeted, innovative research necessary to provide the life-changing answers that everyone living with autism.
“Get up and Give” to support N of One!

N of One: Autism Research Foundation
09/18/2019

N of One: Autism Research Foundation

Schedule your gift today! https://www.northtexasgivingday.org/index.php?section=organizations&action=newDonation_org&fwI...
09/10/2019

Schedule your gift today!

https://www.northtexasgivingday.org/index.php?section=organizations&action=newDonation_org&fwID=1682

The views around autism are beginning to change opening up funding for new areas of study. N of One has been an active participant in fostering this change. Targeted, innovative research is happening, and we are getting closer to life-changing answers. This is progress! DONATIONS DRIVE PROGRESS.

Next week on September 19th, N of One: Autism Research Foundation is holding its annual, one-day online fundraiser powered by North Texas Giving Day. But, you don’t have to wait the 19th to support N of One, you can schedule your gift now! #getupandgive #NTXGD #whyigive #nofoneautismresearchfoundation

“There is good circumstantial evidence that’s growing that a number of mental illnesses are associated with immune dysfu...
07/11/2019
The Reason Anxious People Often Have Allergies

“There is good circumstantial evidence that’s growing that a number of mental illnesses are associated with immune dysfunction,” says Sandro Galea, a physician and epidemiologist at the Boston University School of Public Health.

More evidence of a gut/immune/brain axis.

There is an intricate relationship between gut bacteria, the immune systems, and neurological function. When one is out of balance, there are repercussions in other areas. Understanding this complicated interrelationship will lead to major breakthroughs for autism and likely a host of other mood and neurological disorders. Research is the only path to major breakthroughs.

For the moment, Medicine is still stuck in the old paradigm of the brain as a largely isolated organ, but thought leaders are slowly starting change their views. The paradigm change is happening.

There might be a hidden link between seasonal sniffles and mood disorders.

Because summer is the perfect time to host an outdoor donation stand, we have extended the deadline for Fundraise and Fl...
06/13/2019
#MakeAStandForAutism

Because summer is the perfect time to host an outdoor donation stand, we have extended the deadline for Fundraise and Fly!

You have ALL summer to host a stand and
WIN 2 ROUND TRIP TICKETS by raising money for autism research!

#MakeAStandforAutism and Create an online “stand” to begin your own personal fundraiser by clicking here: makeastandforautism.nofone.org

The fundraising stand that raises the most funds by 12 AM (CST) on AUGUST 15 wins the tickets! We will post updates to show who is fundraising…and at 9 AM (CST) on AUGUST 16, we will post who WILL FLY!

For information on HOW to host a fundraiser, click here: https://docs.wixstatic.com/…/fad8bf_f4451856ac5948b78ba44e0…
Fundraise & Fly promo details: https://docs.wixstatic.com/…/fad8bf_03956078e9b445bbb0ca505…

Please join me in making a stand for kids with autism! #MakeAStandForAutism is a national campaign with the purpose of creating a community supported effort to raise funding, awareness and hope for kids with autism. This is a campaign for EVERYONE to support that is fearlessly led by siblings of chi...

This article describes the recent successful f***l transplant trials in autism at Arizona State and discovery that stool...
05/31/2019
More evidence that autism is linked to gut bacteria

This article describes the recent successful f***l transplant trials in autism at Arizona State and discovery that stool from children with autism can cause normal healthy mice to develop autism-like symptoms at Cal Tech as the beginning of a PARADIGM SHIFT in medicine.

This is a good day for those of us who have been advocating for more focus on the microbiome and other areas in autism.

Article is free if you register (no subscription required)

Understanding that link may be crucial to treatment

Researchers were able to induce autism-like behaviors in mice by transferring over their microbiomes.Read about how N OF...
05/31/2019
Gut bacteria may contribute to autism symptoms, mouse study finds

Researchers were able to induce autism-like behaviors in mice by transferring over their microbiomes.

Read about how N OF ONE SUPPORTED Cal Tech Researcher Sarkis Mazmanian and a dream team of microbiome researchers are advancing the idea that the microbiome matters in autism.

"Genes are a powerful driver of risk for autism, but some researchers suspect another factor is also at play: the set of bacteria that inhabits the gut."

F***l transplants from children with autism reduce social behavior in mice

THANK YOU to everyone who has supported the #MakeAStandForAutism movement so far! We love seeing the photos that you sen...
05/22/2019

THANK YOU to everyone who has supported the #MakeAStandForAutism movement so far! We love seeing the photos that you send!

Our home state of #Texas is showing up strong - this time with a very successful yard sale! This effort is one of many run by the Plakidas Family who have three children - the two oldest being affected by #autism. Their real world stands and online stands combined have raised over $1500!! Keep up the great work, Plakidas Family!

#ConnectingPeopleWhoCareWithResearchThatMatters

05/21/2019
Make A Stand for Autism Launch Video

You have heard from the siblings in our #MakeAStandForAutism video. Summer is just around the corner! NOW it is time to ACT on behalf of kids with autism and plan your stand!

Create your online stand today at makeastandforautism.nofone.org and begin planning your coordinating real world stand today to help fund groundbreaking research for kids with #autism AND a chance to win two airline tickets!

Plan your stand, then plan your getaway! ✈️

(for more details see here: https://docs.wixstatic.com/ugd/fad8bf_243011bff4e246abadab448831da17dc.pdf)

#MakeAStandForAutism is a grassroots campaign inspired by brothers and sister of kids with autism who want to raise funding and awareness.

“How on Earth could we have spent 20 years and hundreds of millions of dollars studying pure noise?”Important article ab...
05/18/2019
A Waste of 1,000 Research Papers

“How on Earth could we have spent 20 years and hundreds of millions of dollars studying pure noise?”

Important article about how an entire field of science can get it wrong and why that happens. Sound familiar?

N of One was founded on the premise that the role of genetics has been historically overemphasized in autism and that our most promising breakthroughs lie outside of genetics. To learn more, visit our website www.NofOne.org

Other Notable Quotes:

“We’re told that science self-corrects, but what the candidate gene literature demonstrates is that it often self-corrects very slowly, and very wastefully, even when the writing has been on the wall for a very long time,”

“There’s an unwillingness to part with a previous hypothesis,” he says. “It’s hard to wrap your head around the fact that maybe you were on a wild goose chase for years.”

“They need to recognize that even those who think they are elite are not immune to poor reproducibility, which leads to a huge amount of waste,”

Decades of early research on the genetics of depression were built on nonexistent foundations. How did that happen?

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N of One was founded by parents and researchers who believe that breakthroughs in autism research that will lead to treatments and prevention strategies are possible in our lifetime. Our goal, is to find diagnostics, treatments, and prevention strategies based on a biological understanding of autism so that every child has a chance of living an independent life.

Autism is now affecting 1 in 59 children. In spite of this alarming rise and after years of research and hundreds of millions of dollars of funding: -We still don't even know what autism is -We don't know what causes it -We don't know how to prevent it -And we don't have any treatments Parents are understandably frustrated with this lack of progress, indeed we all should be. At N of One we have a view that things can be done better and look to partner with parents and researchers who share that view.

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