Cryonics for all?
Bioethics. 2020 Feb 9. doi: 10.1111/bioe.12710. [Epub ahead of print]
To evaluate the state of the art in brain preservation technology. If inexpensive, high quality brain preservation can be proven to work for whole brains, the way it already works for small amounts (1mm cubed) of neural tissue, we want make it every person’s right to preserve their unique and precious personal memories and identities at death, for the possibility of reanimation by future science. Given the rate of accelerating scientific and technological change, AI-guided reanimation might even occur this century, while one's loved ones are still alive.
Mission: To evaluate the state of the art in brain preservation technology. If inexpensive, high quality brain preservation can be proven to work for whole brains, the way it already works for small amounts (1mm cubed) of neural tissue, we want make it every person’s right to preserve their unique and precious personal memories and identities at death, for the possibility of reanimation by future science. Given the rate of accelerating scientific and technological change, AI-guided reanimation might even occur this century, while one's loved ones are still alive.
Cryonics for all?
Bioethics. 2020 Feb 9. doi: 10.1111/bioe.12710. [Epub ahead of print]
The Brain Preservation Foundation has posted a series of videos about the foundation's mission. Enjoy!
Video Documentary Series on the Brain Preservation Foundation Episode 1 – Opening Statement https://youtu.be/v2scSuw0om8 Episode 2 – Redefining the Status Qu...
This article mentions Ken (in a single sentence).
Researchers, scientists and innovators around the world have made it their personal mission to increase the life of humans and help them attain immortality. With every passing year, this distant dream seems that much closer to turning into a reality.
Aldehyde-Stabilized Cryopreservation Wins Final Phase of Brain Preservation Prize
ASHBURN, Va. (PRWEB) March 13, 2018 -- Using a combination of deadly glutaraldehyde fixation and cryogenic storage, researchers have demonstrated a way to preserve a brain’s connectome (the 150 trillion synaptic connections presumed to encode all of a person’s knowledge) for centuries-long stora...
BPF President Kenneth Hayworth posted a new video introducing the current state of the art in Brain Preservation (Aldehyde Stabilized Cryopreservation) and sharing his vision for how it could transform our world. https://t.co/265qyzWuPx
This video gives a brief introduction to the concept of using Aldehyde-Stabilized Cryopreservation (ASC) as a last resort medical intervention for terminal p...
Have you ever wondered whether your brain would be able to adapt to a new set of sensory inputs?
Let’s imagine that in a hypothetical future world, head transplants become possible, as somehow the massive technical challenge of reattaching the brain to the spinal cord can be overcome. This would raise an empirical question: is your brain able to adapt to the novel sensory inputs? An analogous q...
Cryonics in the Courtroom: Which Interests? Whose Interests?
A new study has used connectome data to construct a neural simulation from a part of the Drosophila visual system.
A new manuscript from Gornet et al. describes their work using a serial electron micrograph-derived Drosophila connectome to simulate motion-detection in neurons in the T4 area of the optic lobe: They used the simulation tool NEURON, which is a wonderful and widely-used tool for predicting the elect...
Euthanasia and cryothanasia.
How does cryopreservation affect cellular gene expression? Not very much, at least in a few recently studied cell lines.
In cryobiology, it is generally thought that cellular gene expression profiles do not change substantially following cryopreservation. This is important because if viability cannot be directly shown in a preservation protocol, such as brain cryopreservation, then we are forced to use clues in order…
A lot of the damage in current vitrification protocols is due to rewarming. Researchers have proposed a new way we might be able to avoid it.
A manuscript by Manuchehrabadi et al. about using magnetic nanoparticles to improve rewarming of vitrified tissue samples made quite a splash when it was published earlier this month.
Here are the slides for Keith Wiley's recent EFTF talk.
You have to click the text link below. Clicking the image only links to the thumbnail, not the PDF. Stupid FB.
Imagine if we could safely store the contents of our brains before we die.
Thoughtful media coverage of Cryonics in Australia. This was forwarded to us by Philip Rhoades of the Neural Archive Foundation over there.
Unfortunately, Philip recently lost both of his parents to aging, and unusually, his foundation was personally involved in cryonic suspension of both of them, as described in the article.
We here at BPF are working hard to find validated preservation procedures (ideally, both chemopreservation and cryopreservation) that leading neuroscientists agree should allow later recovery of memory and identity.
We're making good progress, but we have many challenges ahead If you think our work is of value, and that you and your loved ones might need it in the future, please visit our site, join our Newsletter, donate to our nonprofit's cause, volunteer with us, and spread the word about our work. Thanks!
WHEN Philip Rhoades’ parents died within 10 days of each other in May this year there was no question what would be done with their neurological remains.
Did you know that vegans might be more interested in cryonics? Read why and other insights from the Less Wrong 2016 survey:
The Less Wrong (LW) extended community recently conducted a survey of their members...
'Brain Prize' for UK research on memory mechanisms (unrelated to BPF prize): https://t.co/MBMZVsmeaW
Three British researchers win a one million-euro prize for their work on how memories are stored inside the brain.
PubMed: A resource from 3D electron microscopy of hippocampal neuropil for user training and tool development.: https://t.co/QxOlUKx0cq
Sci Data. 2015 Sep 1;2:150046. doi: 10.1038/sdata.2015.46. eCollection 2015. Dataset; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
What can we learn from an insect brain preserved as a carbon film?
ICYMI: Our survey about attitudes towards brain preservation in 2015 found that 32% of people would be more likely to elect for brain preservation if a friend or family member signed up. What about you?
BPF’s 2015 Attitudes About Brain Preservation Survey By Andy McKenzie Posted September 2, 2015 In Survey 1 0 One of the key components of the vision of the Brain Preservation Foundation is “a series of social changes in all free societies to ensure that each of us has the option of exercising the…
Check out our interview with @AdamMarblestone about the likely synaptic proteins that shape & constrain circuitry: https://t.co/8cdiUlJvNV
Biography: Adam Marblestone, PhD (personal website) is developing new approaches to accelerate brain science. He is currently a research scientist and Director of Scientific Architecting with the Synthetic Neurobiology group at MIT, led by Ed Boyden, where he invents and analyzes new technology conc…
PubMed: LTP enhances synaptogenesis in the developing hippocampus.: http://t.co/bOlHyR9F68
Hippocampus. 2015 Sep 29. doi: 10.1002/hipo.22536. [Epub ahead of print]
"Yes, I think mind uploading is possible and even inevitable" - Princeton Neuroscientist Michael Graziano http://t.co/ogFWQIGtSj
Biography: Michael Graziano (Wikipedia) is a scientist, novelist, and composer, and is currently a professor of Psychology and Neuroscience at Princeton University. His previous work focused on how the cortex monitors the space around the body and controls movement within that space, including groun…
Check out BPF Fellow Michael Cerullo's article on the ethics of (chemical) brain preservation: http://t.co/unNjQX2lrU
Life ExtensionThroughout most of human history there was little serious reason to debate the ethics of life extension. To quote Hobbes, most lives were “Nasty, brutish, and short.” Yet the lack of success didn’t stop hopes for miraculous life extension and such hopes have been pursued throughout rec…
The Brain Preservation Foundation has a new website! Browse our competitor submissions and check it out http://www.brainpreservation.org/advisors/
PubMed: An automated images-to-graphs framework for high resolution connectomics.: http://t.co/8NGUvSLqjV
Front Neuroinform. 2015 Aug 13;9:20. doi: 10.3389/fninf.2015.00020. eCollection 2015.
Reddit user monte847 describes why they believe that uploading a preserved mind is exactly equivalent to reviving that mind to the subjective experience of life. Where do you stand on this? https://www.reddit.com/r/Futurology/comments/3ex5hg/freeze_it_then_scan_it_cryonics_mind_uploading/ctjf5y1
Your right that from a scientific standpoint, the copy being a copy isn't a debate, its clearly going to be a copy. However there very much is a...
"You can have your body buried and it provides for cremation but is there really a state interest, a valid and overriding state interest, that would justify restricting a person’s right to choose the third option, namely to have one’s body preserved by means of ultra-low temperatures?" - read more about Keegan Macintosh and the Lifespan Society of B.C.'s civil claim here: http://news.nationalpost.com/news/canada/claim-challenges-b-c-s-ban-on-sale-of-cryonics-preserving-bodies-at-low-temperatures-after-death
B.C. is the only jurisdiction in the world that prohibits the sale or offer for sale of cryonics services, the plaintiffs’s notice states
BPF fellows Michael Cerullo and Keith Wiley have written a fascinating post about personal identity. Do you agree?
Brain Preservation and Personal Identity Part I This will be the first in a series of articles discussing brain preservation, personal identity, whole brain emulation, and mind uploading. Each article will introduce and consider a single focused concept, and therefore will not represent a full prese…
Here is an interview with the Naovaratpong family, who recently elected to cryopreserve their two year old daughter with brain cancer after other options had been exhausted:
Imaging of the islet neural network.
Related Articles Imaging of the islet neural network. Diabetes Obes Metab. 2014 Sep;16 Suppl 1:77-86 Authors: Tang SC, Peng SJ, Chien HJ Abstract The islets of Langerhans receive signals from the circulation and nerves to modulate hormone secretion in response to physiological cues. Although the…
Voxelwise eigenvector centrality mapping of the human functional connectome reveals an influence of the catechol-O-methyltransferase val158met polymorphism on the default mode and somatomotor network.
An examination of ~ 39,000 year old woolly mammoth brain preserved in the permafrost of Siberia shows good gross preservation, as well as similarities to elephant brains:
Estimating Large-Scale Network Convergence in the Human Functional Connectome.
Brain network alterations and vulnerability to simulated neurodegeneration in breast cancer.
The Brain Preservation Foundation just posted its first major prize update in some time, and the progress has been substantial! Read BPF President Kenneth Hayworth's summary of the recent ongoings and then let us know what you think: http://blog.brainpreservation.org/2015/05/26/may-2015-bpf-prize-update/
May 2015 BPF Prize Update Executive Summary Brain Preservation Prize competitor Shawn Mikula just published his whole mouse brain electron microscopy protocol in Nature Methods (paper, BPF interview), putting him close to winning the mouse phase of our prize. Brain Preservation Prize competitor 21st…
In one survey, the most common probability estimate of cryonics "working" was 10%. What do you think? And more importantly, why do you think that? Let us know in the comments!
New PubMed article about neuronal connectomics: Structurally-constrained relationships between cognitive states in the human brain.
The BPF recently conducted an interview with Michael Graziano, which touched on the evolution of consciousness, as well as mind uploading. Check it out: http://blog.brainpreservation.org/2015/04/22/michael-graziano-on-the-evolution-of-consciousness-and-mind-uploading/
Michael Graziano on The Evolution of Consciousness and Mind Uploading April 22, 2015 by BPF Admin No comments Biography: Michael Graziano (Wikipedia) is a scientist, novelist, and composer, and is currently a professor of Psychology and Neuroscience at Princeton University. His previous work focused…
By generating detailed descriptions of tens of thousands of individual neurons, BigNeuron aims to suggest the best computer algorithms for extracting the finely branched shapes of these cells from microscopy data
But effort to catalogue brain’s building blocks may stoke disagreements over classification.
Each time you recall a memory, your feelings about the event can change and become associated with it
New science shows that when memories are attached to particularly emotional events, we're more likely to create a false memory.
“Understanding how the brain works — both in health and disease — is one of the greatest challenges facing mankind”
The gift will streamline the translation of basic research into new therapies for brain injury and disease.
"When they sequenced the genome in the ’90s, people were like, “three to five gigabytes? That’s impossible.” But they did it. Now I’m talking about 200,000 times more, but the world is being pushed toward this, independent of what we do."
MED’s Kasthuri on how our wiring makes us human
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