An ambitious EC-funded research initiative on epigenetics advancing towards systems biology
A new modeling approach to define the range of chromosome configurations present in a cell population and explore their impact on gene regulation by Edith Heard and Guido Tiana. http://www.cell.com/cell/abstract/S0092-8674%2814%2900361-4
Register now for the Models, Epigenetics and Evolution 2014, an EpiGeneSys TAB workshop http://www.epigenesys.eu/en/activities/upcoming-epigenesys-activities/icalrepeat.detail/2014/05/22/278/-/models-epigenetics-and-evolution-2014-an-epigenesys-tab-workshop
An ambitious EC-funded research initiative on epigenetics advancing towards systems biology
You want to know more about lysine methylation and the relationships between this histone mark and chromatin replication? Go take a look at the following review: http://www.sciencedirect.com/science/article/pii/S1874939914000698
Note to users: Uncorrected proofs are Articles in Press that have been copy edited and formatted, but have not been finalized yet. They still need to be proof-read and corrected by the author(s) and the text could still change before final publication.
"The fly transcriptome is substantially more complex than previously recognized". Learn more in Nature http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12962.html#t
Indeed, more genes and transcripts have been identified in Drosophila.
Nature | Article OpenPrintEmailShare/bookmarkCiteULikeFacebookTwitterDeliciousDiggGoogle+LinkedInRedditStumbleUponNext articleNature Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides Diversity and dynamics of the Drosophila transcriptomeJames B. Brown1, 2, 13Nath...
Modelling Approaches in Epigenetics 2014 workshop with @blueprint_eu
http://www.epigenesys.eu/en/activities/upcoming-epigenesys-activities/icalrepeat.detail/2014/03/20/274/-/modelling-approaches-in-epigenetics-2014-an-epigenesys-and-blueprint-joint-workshop
It will take place in Cambridge the 20th and 21th of march.
An ambitious EC-funded research initiative on epigenetics advancing towards systems biology
Call for Abstract: Epigenetics, Chromatin & Transcription (COLD SPRING HARBOR ASIA CONFERENCES): deadline on Feb 23, 2014!!!
http://www.csh-asia.org/2014meetings/EPITRANS.html
We are pleased to announce the 3rd Cold Spring Harbor Asia conference on Epigenetics, Chromatin & Transcription which will be held in Suzhou, China, located approximately 60 miles west of Shanghai. The conference will begin at 7:00pm on the evening of Monday May 5, and will conclude after lunch on F...
The teams of V. Colot (IBENS, Paris, France) and F. Johannes (GBiC, University of Groningen, Netherlands), show that the physical basis of heredity can also occur in the form of epigenetic marks in Arabidopsis taliana.
http://www.sciencemag.org/content/early/2014/02/05/science.1248127.abstract
Quantifying the impact of heritable epigenetic variation on complex traits is an emerging challenge in population genetics. Here, we analyze a population of isogenic Arabidopsis lines that segregate experimentally induced DNA methylation changes at hundreds of regions across the genome. We demonstra...
Tomorrow, don't forget the 1st Who am I? workshop about epigenetics and evolution in Paris Diderot UNiversity.
http://www.labex-whoami.fr/en/news/280-epigenetics-and-evolution-who-am-i-workshop
The first Who am I? workshop - epigenetics and evolution: four different perspectives - will be held on January 22, 2014 from 10.30am to 4pm.
Learn the bases of genetics and epigenetics by looking at Jonathan Weitzman talk during the WikiStage experience around the Curiosity theme.
http://www.youtube.com/watch?v=_Nek_3iNtW8
Your own WikiTalk? Your own WikiStage event? Watch more talks? Go to: www.wikistage.org
Happy new year to all!
Transcription Recovery after DNA Damage Requires Chromatin Priming by the H3.3 Histone Chaperone HIRA
http://www.sciencedirect.com/science/article/pii/S0092867413010234
A cell paper published by S. Adam, S.E. Polo and G. Almouzni in 2013 (Cell 155, 94–106. Doi :10.1016/j.cell.2013.08.029)
How transcription restarts in chromatin regions that have been silenced in response to DNA damage remains poorly understood. Here, they show in human cells that the histone chaperone HIRA deposits newly synthesized H3.3 histones at sites of UVC irradiation in a manner coupled to early ubiquitylation events associated with DNA damage detection. This early and transient function of HIRA is required for transcription reactivation once repair is complete and thus, they propose that HIRA-mediated histone deposition can act as a chromatin bookmarking system for transcription recovery after genotoxic stress.
S. Adam, S.E. Polo and G. Almouzni (Cell, 2013, 155, 94–106. Doi :10.1016/j.cell.2013.08.029)
A. Tanay and S. Hadjur, 2 #EpiGeneSys members, published the role of cohesin in the organization of chromosomal domain architecture in The EMBO Journal http://www.nature.com/emboj/journal/vaop/ncurrent/full/emboj2013237a.html
Sevil Sofueva, Eitan Yaffe, Wen-Ching Chan, Dimitra Georgopoulou, Matteo Vietri Rudan, Hegias Mira-Bontenbal, Steven M Pollard, Gary P Schroth, Amos Tanay and Suzana Hadjur
To know more about the developmental roles of histone H3 variants and their chaperones, take a look at this new review by D. Filipescu, E. Szenker and G. Almouzni: http://www.sciencedirect.com/science/article/pii/S0168952513000917
You will learn:
- How nuclear reprogramming involves a genome-wide deposition of H3.3 during development.
- Why the incorporation of H3.3 is critical to sustain several differentiation programs.
- That the propagation of CenH3 at centromeres through the cell cycle proceeds with different dynamics during development.
Dan Filipescu, Emmanuelle Szenker and Geneviève Almouzni
To know more about the RNAi mechanism, take a look at the video here: http://www.nature.com/news/mammals-chop-up-viral-rna-to-attack-infection-1.13600
Two controversial studies suggest antiviral mechanism called RNA interference may exist in vertebrates after all.
Natural epigenetic variation of wild Arabidopsis thaliana used as a sample for the new Nature: Scientific data that will be launched in May 2014.
http://www.nature.com/sdata/2013/samplearticle2.html
Scientific Data | Data Descriptor PrintShare/bookmarkCiteULikeFacebookTwitterDeliciousDiggGoogle+LinkedInRedditStumbleUponPrevious articleScientific Data | Data Descriptor Sample Data Descriptor: Proteomic profiles of human embryonic stem cells, induced-pluripotent stem cells and precursor fibroblas...
Chromosomes Are Shaped Less Like X's, More Like O's
http://www.theatlantic.com/technology/archive/2013/09/update-chromosomes-are-shaped-less-like-xs-more-like-os/280040/
Tic-Tac-Toe, it turns out, is weirdly prescient about cell biology.
When X inactivation mechanism is applied to find a treatment against Down's syndrome : http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12394.html
Look for the interview of Edith Heard, one of the permanent members of the EpiGeneSys network : m.guardian.co.uk/science/2013/jun/23/rational-heroes-edith-heard-epigenetics
Epigenetics professor Edith Heard tells Catherine de Lange why she's concerned about too much faith being invested in her field
Even 60 years after the discovery of the double helix, DNA still holds some mysteries...
http://www.nature.com/nature/journal/v496/n7446/full/496419a.html
Epigenetics: Methylation reboot
Nature Reviews Cancer highlights a Genes dev. paper investigating the contribution of epigenetic changes to malignant behaviour by resetting the epigenome of glioblastoma stem cells.
http://www.nature.com/nrc/journal/vaop/ncurrent/full/nrc3513.html
Human genetic studies and studies in model organisms provide insight into chromatin regulatory mechanisms in neural development and their role in cognitive deficits, such as intellectual disability.
http://www.nature.com/nrg/journal/vaop/ncurrent/full/nrg3413.html
In March, PhD and Master students came to the Institut Curie to follow the 9th Course on Epigenetics.
Follow the link to learn more about them and epigenetics.
http://www.mysciencework.com/en/MyScienceNews/9861/epigenetics-a-field-in-exponential-evolution
Last week, PhD and Master students from various European research organizations came to the Institut Curie to follow the 9th Course on Epigenetics. This field of biology, known since the 40’s, has taken advantage of technical improvements to grow rapidly over the last 15 years. Nowadays, it ap...
You can listen to Mario Suvà drawing parallels between pluripotent stem cells and programmable cancer cells on Science podcast.
http://www.sciencemag.org/content/339/6127/1567/suppl/DC1
Part of a special issue on cancer genomics, Mario Suvà draws parallels between pluripotent stem cells and programmable cancer cells.
http://blogs.plos.org/attheinterface/2013/03/14/method-and-madness-in-science-and-art/
EpiGeneSys already brings together art and science.
See more on http://www.epigenesys.eu/index.php/en/science-and-you/art-and-science
A strange thing has happened to scientists: increasingly, articles assure us, we are ‘cool’. Perhaps it is the rise of Silicon Valley and of a generation of telegenic science presenters that is making the scientist and researcher start to seem like a bit of a rock star or even (dare I say it) a famo...
Would any researchers out there be interested in blogging on www.epigenesys.eu? We're a European community of epigenetics researchers with a systems biology view.
Ideas for blogs:
-review/summary of recent papers
-exciting story from the lab (this is why I love science)
-bioethical issues
-others?
An ambitious EC-funded research initiative on epigenetics advancing towards systems biology
Untitled Album
What's EpiGeneSys? Watch this
http://www.epigenesys.eu/index.php/fr/in-the-news/multimedia/60-videos/404-epigenesys-shaping-the-future-of-epigenetics-research-in-europe
“ Creativity is not the sole domain of the arts, science is one of the [domains] where I find creativity all over... ” - Paul L. Harrison, University of Dundee, Visual Research Centre (VRC) Print
Would any researchers out there be interested in blogging on www.epigenesys.eu? We're a European community of epigenetics researchers with a systems biology view.
Ideas for blogs:
-review/summary of recent papers
-exciting story from the lab (this is why I love science)
-bioethical issues
-others?
An ambitious EC-funded research initiative on epigenetics advancing towards systems biology
EpiGeneSys FP7's cover photo
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An ambitious EC-funded research initiative on epigenetics advancing towards systems biology
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