Research Group NG Larsson

Research Group NG Larsson We study the organization of the mitochondrial genome, mitochondrial gene expression, mitochondria in ageing and mitochondria in neurodegenerative diseases

Wie gewohnt öffnen

....read about new tool to study mitoribosomes in vivo. Congrats Jakob Busch et al!!!
05/11/2019
MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition

....read about new tool to study mitoribosomes in vivo. Congrats Jakob Busch et al!!!

Busch et al. generated MitoRibo-Tag mice to study mitoribosome composition in vivo in different tissues. Proteomics of MitoRibo-Tag mice with defective assembly identified PUSL1 as a mitoribosome-interacting protein required for efficient mitochondrial translation. MitoRibo-Tag mice provide a tool...

Read about latest research from our lab!  Eduardo Silva Ramos et al. Check also the preview in the same issue https://jo...
11/06/2019
Mitochondrial fusion is required for regulation of mitochondrial DNA replication

Read about latest research from our lab! Eduardo Silva Ramos et al.
Check also the preview in the same issue https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008140

Author summary Mammalian mitochondria contain multiple copies of the mitochondrial genome (mtDNA), which encodes genes that are essential for the oxidative phosphorylation system. An important feature of mtDNA is that it is evenly distributed throughout the mitochondrial network. Dynamin-related GTP...

mtDNA/ fruit flies/ ageing new paper from our lab!!!!!
26/09/2018
Mutations of mitochondrial DNA are not major contributors to aging of fruit flies

mtDNA/ fruit flies/ ageing new paper from our lab!!!!!

Mutations of mtDNA accumulate in aging humans and other mammals to cause mitochondrial dysfunction in a subset of cells in various tissues. Furthermore, experimental induction of mtDNA mutations causes a premature aging syndrome in the mouse. To study if mitochondrial dysfunction is universally invo...

A new collaborative publication with Moraes lab and Stewart lab is now out! Read how to decrease the level of mitochondr...
24/09/2018
MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation

A new collaborative publication with Moraes lab and Stewart lab is now out! Read how to decrease the level of mitochondrial DNA molecules carrying a pathogenic mutation in the newest volume of Nature Medicine. Check also the accompanying paper from Gammage et al.

https://www.nature.com/articles/s41591-018-0166-8
https://www.nature.com/articles/s41591-018-0165-9

Mitochondrial-targeted TALENs reduce mutation burden and correct biochemical defects in a mouse model of mitochondrial disease.

Want to work with mitochondrial genetics? We are now hiring 1-2 postdocs in our lab in Stockholm, Sweden. Apply before 2...
19/06/2018
1-2 Postdoctoral researchers in Mitochondrial Genetics : Stockholm, Sweden : Naturejobs

Want to work with mitochondrial genetics? We are now hiring 1-2 postdocs in our lab in Stockholm, Sweden. Apply before 25th of June!
https://www.nature.com/naturejobs/science/jobs/646575-1-2-postdoctoral-researchers-in-mitochondrial-genetics

1-2 Postdoctoral researchers in Mitochondrial Genetics - Karolinska Institutet (KI) are looking for a Other in Stockholm, Sweden. Salary: unspecified, Hours: Full-time, Type: Contract

Not from our department but hey, same institution and it's about mitochondria 😎 Are you feeling blue due to the low sens...
19/05/2018
A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency. - PubMed - NCBI

Not from our department but hey, same institution and it's about mitochondria 😎
Are you feeling blue due to the low sensitivity of your COX/SDH staining? There is now a new staining in town, NBTx! 🎨
Use it to visualize and quantify mitochondrial COX defects in your favourite model organism.
https://www.ncbi.nlm.nih.gov/pubmed/29660116

J Pathol. 2018 Apr 16. doi: 10.1002/path.5084. [Epub ahead of print]

A new collaborative publication with Aleksandra Filipovska and Oliver Rackham is now out! It is open access so if you ar...
06/04/2018
PTCD1 Is Required for 16S rRNA Maturation Complex Stability and Mitochondrial Ribosome Assembly

A new collaborative publication with Aleksandra Filipovska and Oliver Rackham is now out! It is open access so if you are curious what pentatricopeptide repeat domain protein 1 ( PTCD1) is doing in mitochondria, now is your chance to find out.
http://www.cell.com/cell-reports/abstract/S2211-1247(18)30375-9

Perks et al. engineered intron-exon boundaries using CRISPR/Cas9 to conditionally knock out Ptcd1 in mice. The RNA-binding protein PTCD1 is essential for heart function and regulates the stability and maturation of the 16S rRNA. PTCD1 is required for mitoribosome biogenesis, mitochondrial function,....

☀️Spring is coming and so are the publications! 🐣In humans, mutations in mitochondrial genome maintenance exonuclease 1 ...
24/03/2018
Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria

☀️Spring is coming and so are the publications! 🐣In humans, mutations in mitochondrial genome maintenance exonuclease 1 (MGME1) lead to a disease. In our newest publication we characterize MGME1 knockout mouse model. What are the differences and similarities? It's Open Access so go find out!
https://www.nature.com/articles/s41467-018-03552-x

It has been debated whether premature ageing in mitochondrial DNA mutator mice is driven by point mutations or deletions of mtDNA. Matic et al generate Mgme1 knockout mice and show here that these mice have tissue-specific replication stalling and accumulate deleted mtDNA, without developing progeri...

A new collaborative publication with Claes Gustafsson is now out! Check out the stunning electron microscopy pictures sh...
02/01/2018
Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA

A new collaborative publication with Claes Gustafsson is now out! Check out the stunning electron microscopy pictures showing how Topoisomerase 3 alpha is needed to decatenate mitochondrial DNA.
http://www.cell.com/molecular-cell/abstract/S1097-2765(17)30892-4

Nicholls et al. identify a role for topoisomerase 3α in the separation of mtDNA following replication. Loss of Top3α activity impairs mtDNA segregation and, consequently, segregation of the mtDNA nucleoid within the mitochondrial network. Mutations in TOP3A cause human mitochondrial disease assoc....

A new collaborative publication with Aleksandra Filipovska and Oliver Rackham is now out! Read in Nature Communications ...
20/11/2017
LRPPRC-mediated folding of the mitochondrial transcriptome

A new collaborative publication with Aleksandra Filipovska and Oliver Rackham is now out! Read in Nature Communications how LRPPRC and SLIRP are stabilizing mitochondrial transcripts.
https://www.nature.com/articles/s41467-017-01221-z

The mitochondrial genome, being compressed to 16 kb, is an attractive model system to investigate how RNA-binding proteins chaperone mRNA lifecycles. Here the authors use RNase footprinting and PAR-CLIP to show that the LRPPRC–SLIRP complex stabilizes mRNA structures to expose sites required for…

08/11/2017

We are being spoiled this week with two MitoClubs. Today's talk will be from Junji Hu from the National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China.🕵️‍♀️🎇🎈 At noon, MPI-AGE auditorium

06/11/2017

Due to the time difference between Germany and Japan, this week's MitoClub will already take place on Monday. Today's speaker is Koji Okamoto from the Laboratory of Mitochondrial Dynamics, Osaka University, Japan.
At noon, MPI-AGE auditorium 🤓🍙🌅⛩️

18/10/2017

It's Mitoclub Wednesday!
Today's speaker is William F. Martin from the Institute of Molecular Evolution, Heinrich-Heine-Universität Düsseldorf, DE. MPI-AGE lecture hall at noon if you want to learn more about the origin of mitochondria. 🧠👨‍🏫

And the price goes to......Blob-ology!
04/10/2017

And the price goes to......Blob-ology!

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry 2017 to Jacques Dubochet, Joachim Frank and Richard Henderson “for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution.”

This cool microscope technology has revolutionised biochemistry.

We may soon have detailed images of life’s complex machineries in atomic resolution. The Nobel Prize in Chemistry 2017 is awarded to Jacques Dubochet, Joachim Frank and Richard Henderson for the development of cryo-electron microscopy, which both simplifies and improves the imaging of biomolecules. This method has moved biochemistry into a new era.

A picture is a key to understanding, and scientific breakthroughs often build upon the successful visualisation of objects invisible to the human eye. However, biochemical maps have long been filled with blank spaces because the available technology has had difficulty generating images of much of life’s molecular machinery.

Cryo-electron microscopy changes all of this. Researchers can now freeze biomolecules mid-movement and visualise processes they have never previously seen, which is decisive for both the basic understanding of life’s chemistry and for the development of pharmaceuticals.

Press release: goo.gl/ZpPKjm

Popular information: goo.gl/36TUwC

Advanced information: goo.gl/vBasPu

Congratulations!
03/10/2017

Congratulations!

BREAKING NEWS
The Nobel Assembly at Karolinska Institutet has today decided to award the 2017 Nobel Prize in Physiology or Medicine jointly to

Jeffrey C. Hall, Michael Rosbash and Michael W. Young

“for their discoveries of molecular mechanisms controlling the circadian rhythm”.

Life on Earth is adapted to the rotation of our planet. For many years we have known that living organisms, including humans, have an internal, biological clock that helps them anticipate and adapt to the regular rhythm of the day. But how does this clock actually work? Jeffrey C. Hall, Michael Rosbash and Michael W. Young were able to peek inside our biological clock and elucidate its inner workings. Their discoveries explain how plants, animals and humans adapt their biological rhythm so that it is synchronized with the Earth’s revolutions.

Press release: goo.gl/j7LWaK
Advanced information (pdf): goo.gl/UVTmx3

Raise the awareness. #Mito #MitoAction #MitoAware
17/09/2017

Raise the awareness. #Mito #MitoAction #MitoAware

Many of you might have already returned from your summer holidays so why not start by refreshing your memory 🧠🤔 Check ou...
23/08/2017
The Enigma of the Respiratory Chain Supercomplex. - PubMed - NCBI

Many of you might have already returned from your summer holidays so why not start by refreshing your memory 🧠🤔 Check out some of our most recent reviews on supercomplexes, ageing, fusion and mitochondrial gene expression.

OXPHOS supercomplexes: https://www.ncbi.nlm.nih.gov/pubmed/28380371
Mito and ageing: https://www.ncbi.nlm.nih.gov/pubmed/28094012
Mito fusion: https://www.ncbi.nlm.nih.gov/pubmed/27060252
mtDNA maintenance and expression: https://www.ncbi.nlm.nih.gov/pubmed/27023847

Cell Metab. 2017 Apr 4;25(4):765-776. doi: 10.1016/j.cmet.2017.03.009. Review

13/07/2017
Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila

New collaborative work with W. Kühlbrandt and L. Partridge is now out. Want to know what ultrastructural and functional changes fly and mouse mitochondria have during ageing? Read it all in Elife (open-access).
https://elifesciences.org/articles/24662

Ageing is a progressive decline of intrinsic physiological functions. We examined the impact of ageing on the ultrastructure and function of mitochondria in mouse and fruit flies (Drosophila melanogaster) by electron cryo-tomography and respirometry and discovered distinct age-related changes in bot...

12/07/2017

How time flies. It's again time for a Mitoclub Wednesday!
Today's speaker is Alex Whitworth from the MRC Mitochondrial Biology Unit, Cambridge Biomedical Campus, UK. MPI-AGE lecture hall at noon if you want to learn more about Parkinson's disease in flies. 🐝🔬💡💊📢

The first step in solving a problem is recognizing there is one.Step one: Academic publishing is immensely profitable.St...
28/06/2017
Is the staggeringly profitable business of scientific publishing bad for science?

The first step in solving a problem is recognizing there is one.
Step one: Academic publishing is immensely profitable.
Step two: [This item requires a subscription]

https://www.theguardian.com/science/2017/jun/27/profitable-business-scientific-publishing-bad-for-science

The long read: It is an industry like no other, with profit margins to rival Google – and it was created by one of Britain’s most notorious tycoons: Robert Maxwell

Happy Midsummer!Traditionally, people have lit bonfires in Midsummer's Eve to protect against evil spirits.One wonders w...
23/06/2017
Midsummer - Wikipedia

Happy Midsummer!
Traditionally, people have lit bonfires in Midsummer's Eve to protect against evil spirits.
One wonders whether this would work also against reviewer #2

https://en.wikipedia.org/wiki/Midsummer

, and more specifically the Northern European celebrations that accompany the actual solstice or take place on a day between June 19 and June 25 and the preceding evening. The exact dates vary between different cultures. The

10/06/2017

It's Euromit o'clock!
Our research group has the pleasure of giving three talks:
Today Nina will give a talk in the Young Mitoscientist Forum, on Sunday Nils will give a talk in session I and on Monday session III you can hear Dusanka.

There will also be 14 poster from our students and Postdocs:
A36, A41, A42, A49, A66, A77, A85, A87, B134, B135, C10, C32, C65, C124
We have put a lot of effort in preparing them so come to check them out and talk with us.

#Euromit2017 #YMF

31/05/2017

It's the best kind of Wednesday, a Mitoclub Wednesday!
Today's talk will be given by Thomas Misgeld from the Institute of Neuronal Cell Biology, TU Munich. MPI-AGE lecture hall, at noon. Be there or be inadequately informed 📓🔬🤔

Research Group NG Larsson's cover photo
22/05/2017

Research Group NG Larsson's cover photo

22/05/2017
FASEB > src > micro > site > MitoAg > Home

FASEB meeting of "Mitochondrial Biogenesis and Dynamics in Health, Disease and Aging" started yesterday in West Palm Beach, FL, USA. We have a strong presence in the conference so come to meet us!
On Wednesday Nils will give a talk "Regulation of mtDNA transcription in vivo" and there will be three posters presented by our group members. Rumour has it that one of the posters got even selected for a short presentation 👍🎉
http://www.faseb.org/src/micro/Site/MitoAg/home.aspx

The central role of mitochondria in normal cell physiology is evident from human diseases, including metabolic disorders and aging, which are associated with changes in mitochondrial function. This SRC will facilitate an exchange of knowledge and promote collaborative interactions between investigat...

22/05/2017

Mitochondria cannot be formed de novo but pages can! Welcome to follow the activities of research group NG Larsson.

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